Table 2.
Comparison of clinical parameters between patients with initial CRP levels ≤3 mg/L versus > 3 mg/L
| Characteristics |
CRP ≤ 3 mg/L N = 146 |
CRP > 3 mg/L N = 209 |
P-value |
| Years of age | 62.1 (8.2) | 65.7 (9.8) | < 0.001 |
| Male, N (%) | 77 (53%) | 142 (68%) | 0.004 |
| Current smoker, N (%) | 40 (27%) | 50 (24%) | 0.460 |
| Tobacco consumption, pack years-smoked | 40.3 (19.0) | 39.6 (18.2) | 0.703 |
| FEV1, liters | 1.1 (0.5) | 1.1 (0.5) | 0.922 |
| FEV1,%pred | 41.6 (15.9) | 41.9 (15.9) | 0.846 |
| FEV1/FVC, % | 41.0 (11.8) | 42.7 (11.8) | 0.172 |
| FVC, liters | 3.0 (1.0) | 3.0 (0.9) | 0.884 |
| FVC,%pred | 87.5 (22.5) | 85.4 (20.3) | 0.373 |
| BMI, kg/m2 | 24.0 (4.4) | 25.7 (5.4) | 0.001 |
| PaO2, kPa | 9.3 (1.5) | 9.1 (1.3) | 0.259 |
| PaCO2, kPa | 5.4 (0.8) | 5.5 (0.8) | 0.342 |
| Long-term oxygen therapy, N (%) | 30 (21%) | 52 (25%) | 0.205 |
| 6 minute walking distance, meters | 445.9 (121.2) | 401.1 (129.3) | 0.001 |
| Maximum workload, watts | 77.2 (34.7) | 69.2 (33.0) | 0.037 |
| Maximum workload,% pred | 57.4 (23.6) | 56.0 (26.4) | 0.636 |
| MRC dyspnea score | 2 (2–4) | 3 (2–4) | 0.108 |
| BODE index | 4.1 (2.1) | 4.4 (2.1) | 0.264 |
| Systolic blood pressure, mm/Hg | 134.7 (21.7) | 136.8 (24.4) | 0.412 |
| Diastolic blood pressure, mm/Hg | 80.7 (12.5) | 81.4 (13.5) | 0.647 |
| Charlson co morbidity index † | 1 (1–7) | 1 (1–8) | 0.007 |
| GOLD stages (%): | |||
| Mild | 2.1% | 2.4% | 0.891 |
| Moderate | 27.4% | 23.9% | |
| Severe | 35.6% | 38.3% | |
| Very severe | 34.9% | 35.4% | |
| CRP, mg/L | 1.1 (0.6–1.9) | 9.4 (5.8–16.0) | < 0.001 |
| IL-6, pg/mL | 1.3 (0.7–2.1) | 3.5 (1.6–5.1) | < 0.001 |
| Fibrinogen, g/L | 3.3 (3.0–3.6) | 3.7 (3.4–4.0) | < 0.001 |
*Data presented as mean (standard deviation), median (inter quartile range) or No (%) unless stated otherwise
† Median (range)