Table 3.
Tagging SNPs characteristics and single SNP association analysis for COPD
| dbSNP No. | tagSNP* | Gene region | Minor allele frequency | P-value alleles† |
OR adj‡ genotypes (95%CI) |
P-value genotypes | |
| Controls | COPD | ||||||
| IL6 gene (7p21-p15) | |||||||
| rs2069825 | 205CT/- | 5'flanking | 0.42 | 0.37 | 0.11 | 0.87 (0.64–1.17) |
0.35 |
| rs2069827 | 321G/T | 5'flanking | 0.10 | 0.07 | 0.10 | 0.67 (0.39–1.14) |
0.14 |
| rs1800797 | 1086G/A | 5'flanking | 0.44 | 0.39 | 0.12 | 0.86 (0.64–1.16) |
0.32 |
| rs2069840 | 3437C/G | intron | 0.34 | 0.36 | 0.52 | 1.04 (0.76–1.42) |
0.81 |
| rs1554606 | 3572G/T | intron | 0.46 | 0.42 | 0.19 | 0.84 (0.62–1.13) |
0.25 |
| rs2069849 | 6021C/T | synonymous | 0.03 | 0.02 | 0.33 | 0.51 (0.19–1.36) |
0.18 |
| rs2069861 | 6519C/T | 3'flanking | 0.11 | 0.09 | 0.24 | 0.93 (0.57–1.52) |
0.77 |
| rs1818879 | 7592G/A | 3'flanking | 0.32 | 0.39 | 0.02 | 1.49 (1.08–2.04) |
0.01 |
| CRP gene (1q21-q23) | |||||||
| rs3091244 | 1440C/T | 5'flanking | 0.30 | 0.31 | 0.08 | 1.01 (0.73–1.40) |
0.94 |
| 1440C/A | 0.06 | 0.08 | 1.57 (0.88–2.79) |
0.12 | |||
| rs1800947 | 2667G/C | synonymous | 0.05 | 0.08 | 0.03 | 1.80 (0.96–3.37) |
0.06 |
| rs1130864 | 3014C/T | 3' UTR | 0.30 | 0.31 | 0.65 | 1.05 (0.76–1.46) |
0.76 |
| rs1205 | 3872G/A | 3'-flanking | 0.35 | 0.33 | 0.41 | 0.98 (0.73–1.32) |
0.91 |
| rs2808630 | 5237A/G | 3'-flanking | 0.29 | 0.27 | 0.55 | 0.83 (0.60–1.15) |
0.27 |
| rs3090077 | 6469A/C | 3'-flanking | 0.05 | 0.08 | 0.15 | 1.59 (0.86–2.96) |
0.14 |
| FGB gene (4q28) | |||||||
| rs1800791 | 1038G/A | 5' flanking | 0.18 | 0.17 | 0.63 | 0.80 (0.55–1.18) |
0.26 |
| rs1800788 | 1643C/T | 5' flanking | 0.18 | 0.21 | 0.31 | 1.36 (0.94–1.95) |
0.10 |
| rs1800787 | 1744C/T | 5' flanking | 0.21 | 0.20 | 0.59 | 1.10 (0.75–1.61) |
0.62 |
| rs2227421 | 9952A/C | 3' UTR | 0.31 | 0.33 | 0.59 | 1.03 (0.74–1.42) |
0.87 |
* TagSNPs are numbered by position in sequences AF449713 for CRP, AF372214 for IL6 and AF388026 for FGB. Base change common allele/rare allele.
† P value is for the test of allele counting in cases versus controls.
‡ Logistic regression analysis was adjusted for age, sex and tobacco consumption (pack-years smoked)