Table 4.
Frequency distribution in patients and controls and global association tests for haplotypes of IL6, CRP and FGB
| Gene | Haplotype* |
Controls % |
COPD % |
Global test P-values† | |||
| COPD | Ln (IL-6) |
Ln (CRP) |
Ln (fibrinogen) |
||||
| IL6 | H1 1111111 | 17.8 | 16.1 | 0.003 | 0.80 | 0.08 | 0.73 |
| H2 1111112 | 2.4 | 6.2 | |||||
| H3 1112111 | 4.8 | 10.2 | |||||
| H4 1112112 | 27.8 | 25.0 | |||||
| H5 2121211 | 20.1 | 16.1 | |||||
| H6 2121221 | 10.4 | 7.7 | |||||
| H7 2221211 | 10.1 | 6.3 | |||||
| CRP | H1 111121 | 28.7 | 26.6 | 0.09 | Not tested | 0.0004 | Not tested |
| H2 111211 | 30.3 | 24.2 | |||||
| H3 121211 | 4.9 | 8.2 | |||||
| H4 212111 | 29.7 | 30.4 | |||||
| H5 311112 | 5.4 | 7.3 | |||||
| FGB | H1 1111 | 11.9 | 10.3 | 0.28 | Not tested | Not tested | 0.72 |
| H2 1112 | 31.2 | 32.8 | |||||
| H3 1121 | 21.0 | 19.2 | |||||
| H4 1211 | 18.2 | 20.9 | |||||
| H5 2111 | 17.4 | 16.2 | |||||
* 1 codes the common allele and 2 codes the minor allele. IL6 loci are presented in the order rs2069825, rs2069827, rs1800797, rs2069840, rs1554606, rs2069861 and rs1818879. CRP loci are presented in the order rs3091244, rs1800947, rs1130864, rs1205, rs2808630 and rs3090077. FGB loci are presented in the order rs1800791, rs1800788, rs1800787 and rs2227421
† Global test p-value from haplo.score for overall association between haplotypes and trait. The COPD analysis was adjusted for age, sex and tobacco consumption (pack-years smoked). Inflammatory markers levels analyses were adjusted for marker-specific clinical covariates: age, sex and 6MWD (all genes) and BMI (only for CRP).