Table 6.

Association of IL6 haplotypes with COPD and ln(CRP)

	COPD *		Ln (CRP) †
Haplotype	OR (95%CI)	P-value	Coefficient ± SE	P-value
H1	0.92 (0.56–1.51)	0.75	0.005 ± 0.17	0.98
H2	4.82 (1.64–4.18)	0.004	-0.94 ± 0.27	0.0005
H3	1.71 (0.85–3.44)	0.13	-0.12 ± 0.21	0.54
H4	REFERENT		REFERENT
H5	1.01 (0.64–1.60)	0.95	0.01 ± 0.17	0.93
H6	0.93 (0.51–1.67)	0.80	-0.36 ± 0.22	0.10
H7	0.71 (0.37–1.36)	0.3	-0.02 ± 0.24	0.94
Others‡	1.48 (0.79–2.78)	0.22	-0.07 ± 0.20	0.73

* Logistic regression analyses were adjusted for age, sex and tobacco consumption (pack-years smoked).

† Linear regression analyses were adjusted for age, sex, BMI and 6MWD.

‡ Rare haplotypes (frequency < 2.5%) were coded in aggregate as "others"