Table 7.

COPD-related phenotypes and global association tests (P-values) for haplotypes of IL6, CRP and FGB

	Phenotype*
Gene	BODE index	MRC score	6MWD, meters	Maximum workload, Watts	BMI, Kg/m2	FEV1, L
IL6	0.38	0.41	0.48	0.81	0.66	0.22
CRP	0.33	0.41	0.11	0.06	0.56	0.70
FGB	0.74	0.61	0.61	0.64	0.44	0.72

*Global association tests were adjusted for marker-specific clinical covariates selected by backward linear regression. Age and sex were included in all final models.

Other covariates included in regression models per phenotype:

BODE index: smoking status (former/current), P_CO2 (kPa)

MRC score: FEV₁ (liters), smoking status (former/current)

6MWD: FEV₁ (liters), Charlson co morbidity index, diastolic blood pressure, smoking status (former/current).

Maximum workload: FEV₁ (liters), Charlson co morbidity index, diastolic blood pressure, P_CO2 (kPa), height.

BMI: FEV₁ (liters), smoking status (former/current), diastolic blood pressure, PCO2 (kPa)

FEV₁: Height, systolic and diastolic blood pressure, P_CO2 (kPa) and P_O2 (kPa).