Table 4.

Logistic regression analysis of FcγRIIa-H/R131 genotypes in relation to anti-malarial IgG subclasses in the combined study populations

Anti-malarial antibodies	FcγRIIa-H/R131 genotypes	OR† (95% CI)	p value
AMA-1
IgG1	H/H	1.15 (0.57–2.31)	0.70
	H/R	1
	R/R	1.91 (1.00–3.64)	0.05
IgG2	H/H	2.65 (1.43–4.91)	< 0.001
	H/R	1
	R/R	1.34 (0.69–2.61)	0.38
IgG3	H/H	2.26 (1.21–4.22)	0.01
	H/R	1
	R/R	1.38 (0.70–2.72)	0.35
IgG4	H/H	2.93 (1.33–6.41)	0.01
	H/R	1
	R/R	1.15 (0.53–2.48)	0.72
3D7-MSP2
IgG1	H/H	0.10 (0.03–0.20)	< 0.001
	H/R	1
	R/R	0.86 (0.41–1.80)	0.69
IgG2	H/H	2.76 (1.32–4.47)	< 0.001
	H/R	1
	R/R	1.27 (0.66–2.46)	0.48
IgG3	H/H	2.37 (1.28–4.38)	0.01
	H/R	1
	R/R	1.21 (0.62–2.35)	0.58
IgG4	H/H	2.40 (1.29–4.45)	0.01
	H/R	1
	R/R	1.47 (0.74–2.92)	0.27
FC27-MSP2
IgG1	H/H	1.26 (0.65–2.43)	0.50
	H/R	1
	R/R	2.38 (1.29–4.39)	0.01
IgG2	H/H	2.37 (1.28–4.38)	0.01
	H/R	1
	R/R	1.21 (0.62–2.35)	0.58
IgG3	H/H	2.86 (1.50–5.46)	< 0.001
	H/R	1
	R/R	1.45 (0.70–3.02)	0.32
IgG4	H/H	2.46 (1.33–4.55)	< 0.001
	H/R	1
	R/R	1.77 (0.66–2.48)	0.47
Pf332-C231
IgG1	H/H	1.33 (0.68–2.59)	0.40
	H/R	1
	R/R	2.43 (1.31–4.50)	0.01
IgG2	H/H	2.26 (1.21–4.22)	0.01
	H/R	1
	R/R	1.38 (0.70–2.72)	0.35
IgG3	H/H	2.44 (1.32–4.51)	< 0.001
	H/R	1
	R/R	1.18 (0.61–2.30)	0.62
IgG4	H/H	1.79 (0.92–3.49)	0.10
	H/R	1
	R/R	1.33 (0.59–2.97)	0.50