Table 5.

Logistic regression analysis of FcγRIIa-H/R131 genotypes in relation to anti-malarial IgG subclasses in Fulani compared with non-Fulani groups

Anti-malarial antibodies	FcγRIIa-H/R131 genotypes	OR† (95% CI)	p value
AMA-1
IgG1	H/H	0.04 (0.02–0.12)	< 0.001
	H/R	1
	R/R	0.86 (0.42–1.78)	0.69
IgG2	H/H	0.70 (0.35–1.37)	0.30
	H/R	1
	R/R	0.61 (0.34–1.11)	0.10
IgG3	H/H	0.31 (0.17–0.57)	< 0.001
	H/R	1
	R/R	0.69 (0.34–1.38)	0.30
IgG4	H/H	0.59 (0.30–1.15)	0.12
	H/R	1
	R/R	0.90 (0.41–1.95)	0.78
3D7-MSP2
IgG1	H/H	0.10 (0.03–0.20)	< 0.001
	H/R	1
	R/R	0.86 (0.41–1.80)	0.69
IgG2	H/H	2.43 (1.32–4.47)	< 0.001
	H/R	1
	R/R	0.83 (0.41–1.69)	0.61
IgG3	H/H	0.49 (0.26–0.91)	0.03
	H/R	1
	R/R	0.81 (0.40–1.63)	0.55
IgG4	H/H	2.76 (1.45–5.26)	< 0.001
	H/R	1
	R/R	0.59 (0.28–1.25)	0.17
FC27-MSP2
IgG1	H/H	0.53 (0.28–1.01)	0.10
	H/R	1
	R/R	0.86 (0.42–1.78)	0.68
IgG2	H/H	0.45 (0.24–0.85)	0.01
	H/R	1
	R/R	0.70 (0.35–1.37)	0.30
IgG3	H/H	0.13 (0.10–0.26)	0.01
	H/R	1
	R/R	0.76 (0.37–1.57)	0.46
IgG4	H/H	0.70 (0.36–1.39)	0.31
	H/R	1
	R/R	0.97 (0.54–1.74)	0.92
Pf332-C231
IgG1	H/H	1.25 (0.67–2.30)	0.48
	H/R	1
	R/R	0.72 (0.36–1.44)	0.36
IgG2	H/H	0.22 (0.11–0.44)	< 0.001
	H/R	1
	R/R	0.69 (0.34–1.38)	0.29
IgG3	H/H	4.25 (2.28–7.91)	< 0.001
	H/R	1
	R/R	0.91 (0.45–1.84)	0.80
IgG4	H/H	0.10 (0.03–0.20)	< 0.001
	H/R	1
	R/R	0.69 (0.26–1.42)	0.25