Table 2.
Severe malaria and TLR9 allelic-based association analysis
| The Gambia | Malawi | ||||||||
| Case-control | alleles | OR1 | 95% CI2 | p-value3 | OR | 95% CI | p-value3 | ||
| rs187084 | C vs T | 0.98 | 0.82 | 1.16 | 0.81 | 0.82 | 0.66 | 1.01 | 0.06 |
| rs5743836 | C vs T | 0.92 | 0.78 | 1.07 | 0.26 | 0.90 | 0.75 | 1.08 | 0.26 |
| rs352139 | A vs G | 1.08 | 0.93 | 1.25 | 0.33 | 1.21 | 1.01 | 1.45 | 0.04 |
| rs352140 | T vs C | 1.03 | 0.87 | 1.21 | 0.77 | 0.82 | 0.68 | 1.00 | 0.05 |
| Trios | |||||||||
| rs187084 | C vs T | 0.95 | 0.82 | 1.11 | 0.55 | 0.91 | 0.66 | 1.26 | 0.56 |
| rs5743836 | C vs T | 0.95 | 0.78 | 1.16 | 0.62 | 0.82 | 0.59 | 1.16 | 0.26 |
| rs352139 | A vs G | 0.92 | 0.82 | 1.05 | 0.22 | 1.07 | 0.77 | 1.49 | 0.67 |
| rs352140 | T vs C | 1.00 | 0.87 | 1.16 | 0.97 | 0.99 | 0.72 | 1.36 | 0.94 |
1OR = odds ratio,
2 CI = confidence interval
3 for the trios these are TDT p-values