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. Author manuscript; available in PMC: 2009 Mar 25.
Published in final edited form as: Annu Rev Biophys Biomol Struct. 2007;36:79–105. doi: 10.1146/annurev.biophys.34.040204.144521

Figure 5.

Figure 5

Schematic views of lac repressor (R) interacting with large operator-containing DNA molecules in dilute solution. The DNA molecules are shown well separated into domains. The (upper right) expanded view shows R bound to a segment of nonspecific DNA, on which it can slide or hop in one-dimensional processes or engage in three-dimensional association-dissociation reactions in seeking its specific (operator) target site. The (lower right) expanded view shows a repressor molecule doubly bound to two DNA segments, corresponding to an intermediate in the intersegment transfer process. Modified from Reference 80.