Table 3.
Overall response based on neurological rating scales
|
After enrolment and before quinacrine initiation |
After quinacrine initiation |
After quinacrine initiation: adverse-event reported |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Total | Last seen alive | Last seen dead | Total | Last seen alive | Last seen dead | Total | Last seen alive | Last seen dead | |
| Response | 1 (0/1)* | 1 (0/1) | .. | 4 (1/3)† | 3 (0/3) | 1 (1/0) | 4 (1/3) | 3 (0/3) | 1 (1/0) |
| Stable | 17 (7/10) | 10 (1/9) | 7 (6/1) | 4 (2/2) | 1 (0/1) | 3 (2/1) | 3 (2/1) | 1 (0/1) | 2 (2/0) |
| Deterioration | 24 (15/9) | 7 (3/4) | 17 (12/5) | 28 (10/18) | 11 (1/10) | 17 (9/8) | 24 (7/17) | 11 (1/10) | 13 (6/7) |
| Baseline data only* | 29 (27/2) | .. | 29 (27/2) | 4 (4/0) | .. | 4 (4/0) | .. | .. | .. |
| Total | 71 (49/22) | 18 (4/14) | 53 (45/8) | 40 (17/23) | 15 (1/14) | 25 (16/9) | 31 (10/21) | 15 (1/14) | 16 (9/7) |
Data are number (number with non-inherited disease/number with inherited disease). For each individual rating scale, response was predefined in the protocol as an increase of 3 units on the mini-mental state examination, 2 units on the Barthel index, or 2 units on the Glasgow coma scale, and a decrease of 1 unit on the Rankin scale, 3 units on clinical dementia rating (CDR), 1 unit on global impression of change (GIC), 10 units on Alzheimer's Disease Association-cognitive component, and 6 units on the brief psychiatric rating scale. Deterioration was defined as the inverse (decrease or increase respectively); those not meeting criteria for either response or deterioration were defined as stable. Overall response is defined as response on two or more of the neurological rating scales, without deterioration on any other scores measured at the same timepoint at any time during follow-up.
Response compared with baseline at all visits from week 37 through 113 (last seen alive).
Response at one or two visits only followed by deterioration before date last seen alive or death.