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Disruption of fear memory through dual-hormone gene therapy. Bilateral intraamygdala microinjections of ER/GR (n=11; white squares) causes a severe disruption of both auditory (A) and contextual (B) fear memory at 24 hours after conditioning as compared to controls (n=9; black circles). Animals were given a 5-minute acclimation period before testing. The first data point in B (“pre”) illustrates the freezing levels before the test tone presentations. Error bars represent SEM.
