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. 2009 Apr 3;4(4):e5071. doi: 10.1371/journal.pone.0005071

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Kajiwara et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A, Dense SNPs across the genomic regions harboring the three TSHZ genes were evaluated for association. After gene-wide multiple testing correction was carried out using false-discovery rate, with the beta-uniform distribution (FDR-BUM), the three SNPs shown here, with a q-value of <0.20, were identified as significant. B, C, Teashirt3 expression in postmortem samples was analyzed as a function of genotype at the TSHZ3 SNPs rs7255674 (B) and rs4805666 (C). Subjects were genotyped and grouped into homozygotes for the major allele and carriers of at least one minor allele. Teashirt3 gene expression was analyzed with ANCOVA, controlling for APOE4, sex, PMI, and pH. Minor allele homozygotes were pooled into heterozygotes due to the limited numbers.