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. 2009 Apr 10;5(4):e1000371. doi: 10.1371/journal.ppat.1000371

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Control Arg1 ^flox/flox and Arg1 ^−/flox ;LysMcre mice were infected with S. mansoni for 12 or 22 weeks, and survival was monitored. (A) Survival rates for week 12 (n = 21/20) and 22 (n = 12/15) control and Arg1 ^−/flox ;LysMcre mice infected with 35 cercariae or week 22 mice (n = 5/5) infected with 100 cercariae. (B) Survival of control (n = 8) and Arg1 ^−/flox ;LysMcre (n = 9) mice infected with 35 cercariae in the presence of the NO inhibitor aminoguanidine (2.5% in drinking water). Individual serum samples were isolated from control and Arg1 ^−/flox ;LysMcre mice infected with S. mansoni for 9, 12, and 22 weeks. Samples were analyzed for liver enzymes and LPS. (C) AST/GOT. (D) Alkaline Phosphatase. (E) ALT/GPT. (F) Endotoxin. All assays were repeated three times with similar results.