Figure 4. Overview of the S-adenosylmethionine metabolism in P. falciparum.

On the left side, the C1 metabolism is shown comprising the putatively redox-regulated proteins SAMS and SAHH identified in the present work. OAT, which is also suggested as being redox-sensitive, is involved in the formation of ornithine, an important precursor for polyamine synthesis, which is shown on the right side. The trans-sulfuration pathway from homocysteine to cysteine has not been included in the figure. See text for details.