Table 1.
Encapsulation efficiency of different PLGA and PLGA-PEI nanoparticles
| Polymer used | Lactide to Glycolide Ratio | Mol. Wt (Daltons) | % Encapsulation efficiency | Oligo loading a (μg/30 mg nanoparticles) |
|---|---|---|---|---|
| PLGA-5K | 50:50 | ∼ 5000 | 36 ± 4 | 88 ± 10 |
| PLGA-40K | 50:50 | ∼ 40,000 | 43 ± 5 | 104 ± 14 |
| PLGA-100K | 50:50 | ∼100,000 | 17 ± 3 | 42 ± 8 |
| PLGA-75/25 | 75:25 | 76,000-120,000 | 17 ± 3 | 42 ± 5 |
| PLA-100 | 100:0 | 75,000-120,000 | 47 ± 4 | 115 ± 12 |
| PLGA-40K-PEI | 50:50 | ∼ 40,000 | 79 ± 4 | 194 ± 10 |
a
Initial amount of oligo added was 245 μg/30 mg polymer