Table 1.
Mean sex hormone levels, measures of obesity, and cholesterol levels in men treated with any statin, atorvastatin, and simvastatin compared with untreated men
| No statin | Statin | P value | Atorvastatin | P value | Simvastatin | P value | |
|---|---|---|---|---|---|---|---|
| Total testosterone (nmol/l) | 13.4 | 11.9 | 0.006 | 11.4 | 0.006 | 12.47 | 0.13 |
| Bioavailable testosterone (nmol/l) | 4.14 | 3.90 | 0.133 | 3.82 | 0.151 | 3.96 | 0.292 |
| Free testosterone (nmol/l) | 0.284 | 0.263 | 0.228 | 0.259 | 0.308 | 0.266 | 0.125 |
| SHBG (nmol/l) | 35.3 | 29.4 | 0.034 | 27.6 | 0.022 | 31.8 | 0.392 |
| Estradiol (pmol/l) | 23.2 | 24.0 | 0.763 | 24.7 | 0.193 | 24.0 | 0.705 |
| Waist circumference (cm) | 109.6 | 109.8 | 0.919 | 111.9 | 0.26 | 108.3 | 0.513 |
| BMI (kg/m2) | 32.19 | 32.47 | 0.646 | 33.52 | 0.108 | 31.25 | 0.252 |
| Total cholesterol (mmol/l) | 5.04 | 4.58 | <0.001 | 4.64 | 0.001 | 4.50 | <0.001 |
| ADAM score | 4.15 | 4.26 | 0.26 | 4.08 | 0.809 | 4.3 | 0.675 |
P values given for Student's t test comparing treated patients with the untreated group. Significant results (P < 0.01) are shown in boldface. Total testosterone was significantly lower in the statin and atorvastatin groups but not in the simvastatin group. Bioavailable and free testosterone levels were not significantly lower in any group. Both statins were associated with lower cholesterol levels, but none of the groups were significantly different in terms of obesity.