Table 1.
Bezafibrate | All other fibrates | P value for difference | |
---|---|---|---|
n | 12,161 | 4,191 | |
Person-years | 32,091 | 9,067 | |
Mean duration of use (years) | 2.6 | 2.2 | <0.0001 |
Mode year of treatment initiation | 1993 | 1994 | <0.0001 |
Age (years) | |||
50 | 20 | 22 | 0.0112 |
50–59 | 33 | 33 | 0.9840 |
60–69 | 37 | 33 | <0.0001 |
>69 | 10 | 12 | 0.0008 |
Male sex | 52 | 60 | <0.0001 |
History of myocardial infarction | 1 | 1 | 0.7529 |
History of stroke | 0 | 0 | 0.9676 |
History of ACE inhibitor/angiotensin receptor blocker use | 5 | 6 | 0.0018 |
History of calcium channel blocker use | 24 | 22 | 0.1756 |
History of β-blocker use | 16 | 17 | 0.2382 |
History of loop diuretic use | 5 | 5 | 0.2178 |
History of thiazide diuretic use | 9 | 8 | 0.2883 |
History of corticosteroid use | 3 | 3 | 0.6388 |
Never smoker | 19 | 21 | 0.5114 |
Ever smoker | 39 | 41 | 0.5114 |
Not reported | 42 | 38 | <0.0001 |
BMI | |||
<25 kg/m2 | 9 | 8 | 0.0449 |
25–29.9 kg/m2 | 13 | 13 | 0.6363 |
>29.9 kg/m2 | 5 | 6 | 0.0035 |
Not reported | 73 | 72 | 0.0523 |
Number of cases of incident diabetes | 272 | 131 | |
Cases/1,000 person-years (95% CI) | 8.5 (7.5–9.5) | 14.4 (12.1–17.1) | <0.001 |
Data are % unless indicated otherwise. Individuals with baseline diabetes were excluded. History of cardiovascular events and drug use refer to history in the year before cohort entry. P values were generated using χ2 and t tests.