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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: Drug Metab Dispos. 2008 Aug 7;36(11):2219–2226. doi: 10.1124/dmd.108.021790

Figure 1.

Figure 1

Perfusate concentration versus time profiles of unconjugated silybin A (A) and silybin B (B) in isolated perfused livers from wild-type (•) and TR- (○) rats. Silymarin (26 μg/ml) was added to the recirculating perfusate reservoir and livers from male Wistar rats were perfused for 90 min. Concentrations of silybin A and silybin B were determined by LC-MS analysis as described in Materials and Methods. Data are expressed as mean of n=3 livers in each group; mean ± S.E.M at the 90-min timepoint.