. Author manuscript; available in PMC: 2009 Nov 1.

Published in final edited form as: Drug Metab Dispos. 2008 Aug 7;36(11):2219–2226. doi: 10.1124/dmd.108.021790

Table 2.

Apparent Hepatobiliary Clearances of Glucuronide and Sulfate Conjugates and Total (glucuronide+sulfate) Silymarin Flavonolignans Conjugates in WT vs TR^- Rats

Flavonolignan	Cl_{Glucuronide,app} (mL/min)		Cl_Sulfate,app (mL/min)		Cl_{Total conj.,app} (mL/min )
Flavonolignan	WT	TR^-	WT	TR^-	WT	TR^-
SC	3.00 ± 0.89	0.18 ± 0.07^*	2.05 ± 0.78	0.53 ± 0.22^*	5.05 ± 1.66	0.71 ± 0.27^*
SD	9.04 ± 3.57	0.59 ± 0.31^*	2.33 ± 0.97	0.47 ± 0.09	11.37 ± 4.55	1.06 ± 0.33^*
SA	1.34 ± 0.49	0.05 ± 0.01^*	1.50 ± 0.51	0.34 ± 0.02^*	2.84 ± 1.00	0.40 ± 0.03^*
SB	1.21 ± 0.41	0.02 ± 0.00^*	4.15 ± 1.52	0.68 ± 0.13^*	5.36 ± 1.93	0.71 ± 0.13^*
ISA	1.39 ± 0.74	0.05 ± 0.02	7.12 ± 3.24	1.59 ± 0.07	8.51 ± 3.97	1.64 ± 0.09
ISB	0.99 ± 0.73	0.08 ± 0.03	5.04 ± 2.64	1.66 ± 0.32	6.03 ± 3.36	1.74 ± 0.34

Data are expressed as mean ± S.E.M (n=3). Apparent Hepatobiliary clearance (Cl_b,app) is calculated as cumulative amount of conjugated flavonolignans excreted in bile (Ae) divided by the respective AUC_{0→90 min} of the parent flavonolignan in the perfusate.

p<0.05, significantly different from WT