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. 2009 Apr 2;4(4):e4897. doi: 10.1371/journal.pone.0004897

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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A. Immuno-fluorescent staining of representative pancreas in Pdx1-Cre (panel a) and Pdx1-Cre;Vhl f/f mice (panels b and c) to demonstrate the abnormally shaped and hyperplastic islets (red) in Pdx1-Cre;Vhl f/f mice at 16–18 months of age. Images are taken at 100×. B. Immuno-fluorescent images of representative pancreas in Pdx1-Cre (panels a–c) and Pdx1-Cre;Vhl f/f (panels d–i) to demonstrate hypervascularity within islets of Pdx1-Cre;Vhl f/f mice. Blood vessels are visualized via FITC-lectin injection (green; panels b, e, and h) while pancreatic islets are identified using an anti-insulin antibody (red; panels c, f, and i). Images are taken at 200×.