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Binding mode of 1 in the catalytic site of Jak3. The protein is shown with the ribbons representation with the N-lobe colored in cyan, the C-lobe in orange, and the hinge region in yellow. The residues in the binding pocket are colored by atom type. Compound 1 is shown as ball and stick model with carbon atoms colored in green. The major polar interactions between compound 1 and the residues in the pocket are highlighted as dotted lines.
