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Effects of naloxone and the μ-selective antagonist β-FNA on morphine and M6G analgesia. Groups of mice (n = 15–25) receive morphine (4.5 mg/kg) or M6G (3 mg/kg for wild type; 24 mg/kg for knockouts) 24 h after administration of β-funaltrexamine (40 mg/kg) or 15 min after naloxone (5 mg/kg, sc), and are tested in the radiant heat tail-flick assay. Responses in saline and antagonist-treated animals are compared for each opioid analgesic separately by using the Fisher exact test.
