Fig. 1.

Effects of WIN55,212-2 on retention of an inhibitory avoidance response. Step-through latencies (mean and SEM) on a 48-h retention test. (A) Immediate posttraining intra-BLA infusions of the cannabinoid agonist WIN55,212-2 (WIN; 5, 10, 50 ng per 0.2 μL) enhanced memory consolidation. *, P < 0.05 vs. vehicle (Veh; n = 10–11 per group). (B) Delayed infusions of WIN55,212-2 (WIN; 50 ng per 0.2 μL) administered into the BLA 3 h after training did not enhance memory consolidation (n = 11–12 rats per group). (C) Immediate posttraining infusions of WIN55,212-2 (WIN 50 ng per 0.2 μL) into the CeA did not enhance memory consolidation (n = 7 rats per group).