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Hydroxyprogesterone caproate, rosolic acid, and Para are selective GR modulators. (A) Luciferase assays were performed on A549 and U2OS-GR cells transfected with pENaC-luc and pSV40-rl and treated with dex and various drugs as indicated. The relative activity of pENaC-luc with dex treatment was normalized to 100%. Ros, rosolic acid. (B) Relative mRNA levels of the indicated genes were determined by using qPCR. Cells were treated for 24 h as indicated. *, P ≤ 0.05.
