Figure 2.

Effect of pressure on the GdmCl dependence of the apparent rate constant (A) and the equilibrium transition (B) for tendamistat folding at pH 2.0, 35°C. Experiments were carried out at 5 MPa (black), 20 MPa (dark blue), 40 MPa (green), 60 MPa (red), 80 MPa (light blue), and 100 MPa (magenta). The lines represent the result of the global fit of the kinetic and the equilibrium data according to Eqs. 5, 7, 8, 10 and 11. The residuals of the global fits are shown below each panel.