Table 3.

Comparison of protein level abundance and invasion assay results for selected mutant strains of P. gingivalis lacking in functional genes at the locus shown.

ORF (TIGR)	Gene Name	Abundance Change1	Mutant Invasion Phenotype2	Reference
PG0159	pepO	↓	↓	Park et al., 2004 [22]
PG0653	serB	↑	↓	Tribble et al. 2006 [44]
PG1118	clpB	↑	↓	Unpublished (Lamont et al.)
PG1642	zntA	nd	↓	Park et al., 2004 [22]
PG1844	kgp	↓	↓	Park and Lamont, 1998 [45]
FMA3	fimA	↓	↓	Weinberg et al., 1997 [46]
PG2024	rgpA	↓	↓	Park and Lamont, 1998 [45]
PG2206	yjjK	↑	↓	Park et al., 2004 [22]

¹Protein abundance in intracellular P. gingivalis (see supplementary Table S1): ↑ represents over-expression (green dot in the supplement Table S1 and Fig. 1), ↓ represents under-expression (red dot in Table S1), nd represents a qualitative non-detect (white dot in Table S1).

²Ability of a mutant in the regulated gene to invade and survive in gingival epithelial cells as determined by antibiotic protection assays. ↓ represents a reduction in intracellular invasion/survival (p < 0.01). For methods used in the antibiotic protection assays, see [3].

³The ATCC 33277 strain FimA sequence was used in the present studies [41]. The equivalent TIGR ORF for W83 is PG2132.