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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Clin Immunol. 2008 Oct 8;130(1):27–33. doi: 10.1016/j.clim.2008.08.018

Figure 2.

Figure 2

IL-6 exerts its effects on cytokine production through a diverse set of key molecules. Upregulation of SOCS1 expression inhibits IFNγ signals thereby diminishing additional IFNγ production. IL-4 production is mediated through the induction of NFATc2 and c-maf expression. STAT3 directly regulates IL-6 induced IL-21 expression, which therefore precedes expression of the other cytokines. Simultaneous stimulation through IL-6 and TGFβ induces high level expression of RORγt which mediates IL-17 production.