Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Contribution of IL-6 to T helper cell differentiation and subsequent cytokine production by various T cell subsets. IL-6 exerts inhibitory activity towards Th1 and T regulatory (Treg) differentiation/function and promotes Th2 and Th17 differentiation either alone (Th2) or together with TGFβ (Th17). The role of IL-6 in T follicular helper (Tfh) cell differentiation is suggested due to its specific upregulation of IL-21 in naïve CD4 T cells.
