Fig. 2.

Plasma transaminase levels and quantitation of histological changes 24 h after LPS and/or resistin injection. Mice were treated as described under Materials and Methods. Pathology was scored (top panel) as described under Materials and Methods. CAE-positive cells (middle, black bars) and TUNEL-positive cells (middle, gray bars) were quantitated as described under Materials and Methods. ALT (bottom, black bars) and AST (bottom, gray bars) were determined in plasma samples for the 24-h time point. Data are means ± S.E.M. (n = 4–6) and are reported as -fold of control values. ^a, p < 0.05 compared with the absence of LPS; ^b, p < 0.05 compared with the absence of resistin.