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. Author manuscript; available in PMC: 2009 Mar 25.
Published in final edited form as: J Pharmacol Exp Ther. 2008 Mar 13;325(3):801–808. doi: 10.1124/jpet.108.136721.

Fig. 7.

Fig. 7

Effect of Hirudin and U0126 on resistin and LPS-induced PAI-1 expression and liver damage. Mice received injections with resistin, resistin + LPS, or saline as described under Materials and Methods. Realtime RT-PCR (top panel), ELISA for TNFα protein (middle), and spectrophotometric determination of ALT/AST were performed as described under Materials and Methods. Data are means ± S.E.M. (n = 4–6). PCR data are reported as -fold of control values. a, p < 0.05 compared with the absence of LPS; b, p < 0.05 compared with the absence of resistin;c, p < 0.05 compared with the absence of hirudin or U0126. PAI-1 data for control, LPS, and resistin + LPS are derived from Fig. 3 and shown here for comparison. Transaminase data for control, LPS, and resistin + LPS are derived from Fig. 2 and shown here for comparison.