Table 2.
Clinical variables of potential relevance in miGEP studies on human tissues
| Demographics | Age |
| Sex | |
| Race | |
| Genetic factors | Congenital diseases |
| SNPs | |
| Non-SNP polymorphisms | |
| Mosaicism | |
| 'Background' comorbidity (chronic) | Sophistication of clinical documentation |
| Substance abuse/cigarettes | |
| Prescription drugs/supplements | |
| Metabolic disease | |
| Degenerative processes | |
| Major psychiatric disorder(s) | |
| Inflammatory/infectious disease | |
| Prior sugery/transplant | |
| Radiation therapy | |
| Body habitus/nutritional status | |
| Toxic/environmental exposures | |
| Organ function: kidney, liver, lungs, etc. | |
| Acute condition | (see above) |
| Vascular status (blood pressure problem/shock) | |
| External support--respirator, dialysis | |
| Metabolic perturbations | |
| Acute treatment incl chemotherapy, morphine, etc. | |
| State of consciousness incl sleep/wake | |
| Trauma | |
| Related to death/surgery | Single or multi-factorial |
| Biopsy/autopsy confirmed via pathology | |
| Anesthesia | |
| Preanalytical variables | Post-mortem interval |
| Interval prior to freezing/fixative | |
| Tissue pH | |
| Expertise/number of tissue handler(s) | |
| Sophistication of documentation | |
| Detailed information regarding anatomy |