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. Author manuscript; available in PMC: 2009 Mar 25.
Published in final edited form as: Cell. 2006 Mar 10;124(5):997–1009. doi: 10.1016/j.cell.2005.12.038

Figure 5.

Figure 5

The pre-early endosome sorting is independent of pH, but depends on microtubules and endocytic adaptor protein. (A) The effect of ammonium chloride on the balance between the dynamic (maturation time < 100 s) and static (maturation time > 100 s) endosome populations. (B) The effect of nocodazole (30 min treatment) on the balance between the two populations. In (A) and (B), colored histograms are for all endosomes, Tfn-receiving, LDL-receiving, and virus-receiving endosomes in drug-treated cells; shaded histograms are for those in untreated cells. (C) The effect of AP-2 knockdown on the balance between the two populations.