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. 2008 Nov 13;364(1517):689–703. doi: 10.1098/rstb.2008.0193

Figure 3.

Figure 3

(a) LMM A3G restricts HIV-1 after entry into resting peripheral blood CD4 T cells. Human A3G exists exclusively in LMM forms in peripheral blood-derived resting CD4 T cells and functions as a post-entry restriction factor to block replication of incoming HIV-1 viral particles. (b) RNA interference-mediated depletion of LMM A3G in resting CD4 T cells is sufficient to render these cells permissive for HIV-1 infection. (c) This restricting activity is forfeited when A3G is recruited into the HMM A3G complex upon CD4 T-cell activation by various mitogens (anti-CD3/CD28 and phorbol myristate acetate (PMA)) and cytokines (IL-2, IL-7 and IL-15).