Table 3.

The C over G targeting bias generated by AID at the V gene locus is eliminated by the MSH2–MSH6 pathway to generate an A to T mutation bias.

genetic background	percentage of total mutations
	C	G	A	T
	C over G bias (60 : 40)
Ung−/−×Msh2−/−; Rada et al. (2002)	61	38	1	0
Msh2−/−; Rada et al. (2004)	54	36	6	4
Polη−/−×Msh2−/−; Rada et al. (2004)	62	37	0	1
	no C/G bias–A over T bias (70 : 30)
wild-type; Rada et al. (2004)	25	25	34	16
Ung−/−; Delbos et al. (2007)	29	29	29	13
Polη−/−; Rada et al. (2004)	41	43	11	6