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. 2009 Apr 10;5(4):e1000377. doi: 10.1371/journal.ppat.1000377

Figure 3. ES clones show reduced entry efficiency at fixed CD4 surface concentrations.

Figure 3

(A–C,D–F) Affinofile cells were induced to express threshold (approximately 2,500) CD4 molecules/cell (A–C) or maximal (approximately 125,000) CD4 molecules/cell (D–F) and CCR5 molecules ranging from approximately 1274 to 21,073 molecules/cell prior to infection. Infection is performed as described in Figure 2. (B,E) Infectivity of clones from individuals were averaged and plotted as a single line for chronic and ES individuals. P values are given for patient averages. (n = 7) (C,F) Average of all individual chronic or elite env clones at threshold (C) and maximal (F) CD4 concentrations with CCR5 concentrations ranging from approximately 1274 to 21,073 molecules/cell. P values are represented as follows: P<.05 (*), P<.01 (**), P<.001 (***), P<.0001 (***). 95% confidence intervals are shown for chronic (grey) and ES (pink).