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. Author manuscript; available in PMC: 2009 Jul 1.
Published in final edited form as: Clin Cancer Res. 2008 Jul 1;14(13):4200–4205. doi: 10.1158/1078-0432.CCR-07-4592

Table 3.

Comparison of total drug pharmacokinetic parameters for first cycles of nab -paclitaxel and sb-paclitaxel (n=14)

nab -paclitaxel
(260 mg/m2)		 sb-paclitaxel
(175 mg/m2)
Mean Range %CV Mean Range %CV P-value
T ½
(hr) 		20.0 15.5 - 31.2 21.3% 20.9 15.7 - 34.0 21.4% 0.53
Cmax
(ng/mL) 		19,556.4 10,613.1 - 34,201.4 36.2% 5,128.0 3,136.0 - 8,832.3 32.7% <0.00001
Cmax_Dose
(ng/mL per mg/m2) 		75.2 40.8 - 131.5 36.2% 29.3 17.9 - 50.5 32.7% <0.00001
AUCINF
(hr*ng/mL) 		20,324.5 15,539.2 - 29,447.9 19.5% 20,821.1 12,973.4 - 30,622.2 25.9% 0.72
AUCINF_Dose
(hr*ng/mL per mg/m2) 		78.2 59.8 - 175.0 19.5% 119.0 74.1 - 175.0 25.9% 0.0001
Vz_obs
(L/m2) 		375.4 269.6 - 571.1 21.9% 270.8 151.0 - 457.2 61.4% 0.003
Cl_obs
(L/hr/m2) 		13.2 8.8 - 16.7 17.9% 8.9 5.7 - 13.5 25.7% 0.00002