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. Author manuscript; available in PMC: 2009 Jul 1.
Published in final edited form as: Clin Cancer Res. 2008 Jul 1;14(13):4200–4205. doi: 10.1158/1078-0432.CCR-07-4592

Table 4.

Comparison of unbound paclitaxel pharmacokinetic parameters for first cycles of nab -paclitaxel and sb-paclitaxel (n = 14)

nab -pacliataxel
(260 mg/m2)		 sb-paclitaxel
(175 mg/m2)
Mean Range %CV Mean Range %CV P-value
Cmax
(ng/mL) 		1,283.7 419.3 - 2,401.9 41.5% 121.8 65.9 - 198.3 32.5% −<0.000001
Cmax/Dose
(ng/mL per mg/m2) 		4.9 1.6 - 9.2 41.5% 0.7 0.4 - 1.1 32.5% <0.000005
AUCINF
(hr*ng/mL) 		1,158.8 636.6 - 1,759.4 29.1% 409.9 207.3 - 649.3 35.0% <0.000005
AUCINF_Dose
(hr*ng/mL per
mg/m2) 		4.5 2.5 - 6.9 27.4% 2.3 1.2 - 3.7 35.0% 0.0002
AUC 0-4.5
(hr*ng/mL) 		969.2 355.0 - 1,661.9 32.9%
0.0002
AUC 0-7
(hr*ng/mL) 		361.1 193.2 - 589.0 32.3%