Table 3.
Relative expression of genes encoding for proteins involved in lipid synthesis and uptake
| Particle size: 1 μm Exposure time |
2 h | 4 h | 8 h | 12 h | 24 h |
| HMG CoA Synthase | 1.23 (0.34) | 1.33 (0.23) | 0.80 (0.38) | 1.38 (0.42) | 1.26 (0.16) |
| HMG CoA Reductase | 1.37 (0.18) | 1.12 (0.16) | 0.95 (0.16) | 1.41 (0.12) | 1.33 (0.29) |
| LDL Receptor | 1.33 (0.24) | 1.20 (0.21) | 1.06 (0.48) | 1.24 (0.01) | 1.48 (0.31) |
| Fatty Acid Synthase | 1.05 (0.03) | 0.91 (0.09) | 0.92 (0.34) | 0.93 (0.24) | 1.26 (0.46) |
| Particle size: 0.05 μm Exposure time |
2 h | 4 h | 8 h | 12 h | 24 h |
| HMG CoA Synthase | 1.44 (0.38) | 1.11 (0.15) | 1.02 (0.12) | 1.03 (0.24) | 1.00 (0.18) |
| HMG CoA Reductase | 1.08 (0.15) | 0.99 (0.17) | 0.99 (0.05) | 1.03 (0.06) | 1.04 (0.29) |
| LDL Receptor | 1.28 (0.20) | 1.05 (0.05) | 1.06 (0.17) | 0.83 (0.11) | 1.40 (0.42) |
| Fatty Acid Synthase | 1.15 (0.17) | 0.94 (0.04) | 1.09 (0.26) | 0.97 (0.17) | 1.19 (0.40) |
Note: Induction of mRNA of each gene relative to the negative control after different exposure times for 6 × 108 1 μm particles and 4.5 × 1011 0.05 μm particles. The results show the mean of three experiments (standard deviation).