Table 2.
Pathway and toxicity analysis using the Ingenuity Pathway Analysis
| Pathway | P Value | Upregulated Genes | Downregulated Genes |
|---|---|---|---|
| Eicosanoid signaling | 0.0012 | PTGS2 | PTGER4, PTGDS, PTGIS |
| Interferon signaling | 0.0200 | OAS1, IFIT1 | |
| Axonal guidance signaling | 0.0257 | HHIP, CDC42, GNAS | IGF1, NRP2, UNC5B NTRK2 |
| Wnt/β-catenin signaling | 0.0316 | NLK | CDKN2A, SFRP4, SOX4 |
| p53 signaling | 0.0026 | PMAIP1, E2F7 | CDKN2A, UNC5B |
| Hepatic fibrosis | 0.0257 | IL8 | FGF7, IGF1 |
| Hepatic stellate cell activation | 0.0282 | IL8 | IGF1 |
P < 0.05. Shown are genes that are involved in the pathways and gene expression changes.