Skip to main content
. 2009 Apr 4;4(4):e5003. doi: 10.1371/journal.pone.0005003

Table 3. Single tSNP association analyses with EH, BP variation and 24 hour urinary potassium in BRIGHT.

Trait tSNP SNP ID gene positiona Majorb Minorb RAFc Modeld Effecte 95% CIe perm-pe globaL-pf
EH (Odds ratio) 12 rs765250 i1 A G 0.69 Dom 1.3 1.0,1.7 0.01 0.4
SBP (mmHg) 2 rs1468326 5′ C A 0.11 Rec 5.1 0.6,9.2 0.02
3 rs3088353 5′ A C 0.46 Rec 1.6 0.2,2.8 0.02
5 rs2369402 i1 G A 0.21 Dom 1.2 0.1,2.2 0.03
6 rs2107612 i1 A G 0.73 Add 1.2 0.2,2.0 0.008
7 rs2107613 i1 C T 0.23 Dom 1.2 0.1,2.3 0.03
11 rs11064536 i1 T C 0.83 Dom 3.1 0,6.1 0.05
12 rs765250 i1 A G 0.69 Dom 3.1 1.3,4.9 0.0005 0.02
DBP (mmHg) 2 rs1468326 5′ C A 0.11 Rec 3.1 0.01,5.8 0.04
3 rs3088353 5′ A C 0.46 Rec 0.9 0.1,1.8 0.03
5 rs2369402 i1 G A 0.21 Dom 0.8 0,1.5 0.04
6 rs2107612 i1 A G 0.73 Add 0.6 0.01,1.2 0.05
7 rs2107613 i1 C T 0.23 Dom 0.7 0.06,1.4 0.06
11 rs11064536 i1 T C 0.83 Dom 2.5 0.2,4.8 0.02
12 rs765250 i1 A G 0.69 Dom 1.9 0.7,3.2 0.002 0.06
24 hour urine K+ (mmol/24 hour) 3 rs3088353 5′ A C 0.46 Dom −5.9 −2.5,−9.2 0.0004
6 rs2107612 i1 A G 0.73 Add −2.6 −4.8,−0.3 0.03
8 rs11608756 i1 G A 0.61 Add −2.3 −4.3,−0.1 0.04
9 rs11064524 i1 T G 0.25 Dom −7.3 −12.1,−2.2 0.008
12 rs765250 i1 A G 0.69 Add −3.1 −5.4,−0.8 0.009
13 rs12314329 i1 A G 0.08 Add −4.3 −7.8,−0.5 0.03
14 rs11611246 i4 G T 0.78 Add −2.9 −5.3,−0.4 0.02
15 rs6489756 i4 A G 0.47 Add −3.2 −5.6,−0.9 0.005
27 rs2277869 i26 T C 0.84 Add −4.5 −7.6,−1.5 0.004
28 rs11571461 3′ A G 0.07 Add −4.7 −8.7,−0.5 0.03 0.01
a

i: intron, 5′: 5 prime; 3′: 3 prime.

b

Indicates major or minor alleles, bold indicates the allele increasing blood pressure.

c

RAF: Risk Allele Frequency – refers to the allele increasing blood pressure or decreasing urinary potassium.

d

Best Model; Add: Additive, Dom: Dominant, Rec: Recessive.

e

Linear effect estimate, 95% confidence intervals for EH, diagnosis SBP, DBP and 24 hour urine potassium using 10 K bootstrap samples. P-vaules are based on 10,000 permutations.

f

Global p-value based on 10,000 permutations - adjusting for testing multiple SNPs and multiple models.