. 2009 Apr 4;4(4):e5003. doi: 10.1371/journal.pone.0005003

Table 5. Association results of rs765250 with essential hypertension and blood pressure variation per cohort and meta-analyses.

Study	Population	N^a	Case/Control	EH		SBP		DBP
				OR (CI)^b	p-value^c	Effect (se)^b	p-value^c	Effect (se)^b	p-value^c
Original Study	BRIGHT	3400	1700/1700	1.3(1.0,1.7)	0.015	0.04(0.01)	0.0005	0.032(0.011)	0.002
Replication studies	HYPEST	1246	596/650	1.2(0.8,1.8)	0.2	0.02(0.01)	0.03	0.01(0.01)	0.1
	LOLIPOP	943	485/458	1.3(0.8,2.1)	0.1	0.03(0.02)	0.09	0.03(0.02)	0.06
	Whitehall I	1002	466/536	1.2(0.8,1.9)	0.3	0.02(0.03)	0.2	0.01(0.03)	0.3
	ELSA	5422	2323/2745	1.2(1.0,1.5)	0.03	0.02(0.01)	0.008	0.02(0.01)	0.005
	Whitehall II	4867	1247/3620	0.8(0.6,1.0)	0.1	0.004(0.01)	0.3	−0.001(0.007)	0.4
	Olivetti	971	165/447	0.8(0.5,1.3)	0.5	−0.004(0.01)	0.4	−0.01(0.01)	0.2
Meta-Analysis	Replication	14451	5282/8456	1.1(0.9,1.2)	0.3	0.1(0.004)	0.007	0.007(0.004)	0.06
Test for heterogeneity				I² = 30.5%,p = 0.22		I² = 0%,p = 0.42		I² = 40.5%,p = 0.14
Meta-Analysis ^d	Combined	17851	6982/10156	1.1(1.0,1.3)	0.04	0.01(0.004)	0.0002	0.01(0.006)	0.06
Test for heterogeneity				I² = 35.7%,p = 0.16		I² = 39.1%,p = 0.13		I² = 52.9%,p = 0.047

Effective number – maximum number of individuals available for analysis.

Odds ratio and confidence intervals for EH using 10 K bootstrap samples. For the replication cohorts and meta analyses 90% confidence intervals are reported as all analyses were performed with the prior hypothesis that carriers of rs765250 allele A (A/A+A/G vs G/G) would be at increased risk for EH compared to G/G homozygotes.

For the replication cohorts and meta analyses one-tailed p-values are reported.

For EH and SBP results were combined under a fixed effects model. DBP showed evidence for heterogeneity and was analysed using a random-effects model.