TABLE 3.
Associations between study groups and medical conditions related to hemochromatosis
| Symptoms and signs | OR (95% CI) |
|---|---|
| General | |
| Chronic fatigue/weakness last 12 months. | |
| Previously diagnosed | 2.8 (1.34 to 5.95) |
| Newly diagnosed with elevated serum ferritin | 2.0 (1.07 to 3.75) |
| Newly diagnosed with normal serum ferritin | 1.6 (0.66 to 3.68) |
| Controls | 1.0 |
| Arthritis | |
| Joint stiffness/pain/ache in last 12 months. | |
| Previously diagnosed | 1.9 (0.85 to 4.29) |
| Newly diagnosed with elevated serum ferritin | 2.7 (1.38 to 5.30) |
| Newly diagnosed with normal serum ferritin | 2.3 (0.98 to 5.63) |
| Controls | 1.0 |
| Signs on physical examination | |
| Metacarpophalangeal joints swollen or tender | |
| Previously diagnosed | 4.2 (1.37 to 13.03) |
| Newly diagnosed with elevated serum ferritin | 3.3 (1.17 to 9.49) |
| Newly diagnosed with normal serum ferritin | 1.0 (0.11 to 8.75) |
| Controls | 1.0 |
| Increased pigmentation on sun-exposed or unexposed areas | |
| Previously diagnosed versus controls | 4.7 (1.50 to 15.06) |
| Newly diagnosed with elevated serum ferritin | 3.7 (1.10 to 12.16) |
| Newly diagnosed with normal serum ferritin | 4.6 (0.87 to 24.25) |
| Controls | 1.0 |
For signs and symptoms with a significant overall group effect by the Bonferroni multiple comparisons procedure, pairwise comparisons significant at the nominal level (α=0.05) are shown