TABLE 4.
Results of serum biochemical tests in C282Y homozygotes and control participants
| Test* |
C282Y homozygotes |
Control participants (n=364) | Nominal P§ | ||
|---|---|---|---|---|---|
| Previously diagnosed (n=87) |
Newly diagnosed |
||||
| Serum ferritin elevated† (n=131) | Serum ferritin not elevated‡ (n=64) | ||||
| Fasting glucose, (mmol/L) | 5.61 (4.94, 6.22) | 5.22 (4.83, 5.61) | 5.05 (4.80, 5.52) | 5.16 (4.88, 5.66) | 0.062 |
| Fasting insulin, (pmol/L) | 76 (49, 97) | 56 (35, 83) | 56 (42, 76) | 56 (42, 80) | 0.20 |
| Alanine aminotransferase (U/L) | 20.0 (15.0, 30.0) | 22.0 (16.0, 33.0) | 16.0 (11.0, 20.0) | 19.0 (14.5, 25.0) | 0.0047 |
| Aspartate aminotransferase (U/L)) | 22.0 (18.0, 29.0) | 22.0 (19.0, 30.0) | 19.0 (16.0, 21.5) | 21.0 (17.0, 25.0) | 0.040 |
| Gamma-glutamyltransferase (U/L) | 25.0 (17.0, 37.0) | 23.0(15.0, 34.0) | 16.5 (12.0, 29.5) | 19.0 (13.0, 31.0) | 0.070 |
| C-reactive protein >5.0 mg/L, n (%) | 27 (31) | 41 (31) | 25 (39) | 106 (29) | 0.62 |
Data are presented as median (25th percentile, 75th percentile) unless otherwise indicated.
*
Laboratory reference ranges: fasting glucose: 3.3–6.38 mmol/L; fasting insulin: 0–139 pmol/L; alanine aminotransferase: 0–31 U/L (women), 0–40 U/L (men); aspartate aminotransferase: 0–31 U/L (women), 0–37 U/L (men); gamma-glutamyltransferase: 7–33 U/L (women), 11–51 U/L (men); C-reactive protein: 0–5.0 mg/L.
†
Serum ferritin >200 μg/L for women, >300 μg/L for men;
‡
Serum ferritin ≤ 200 μg/L for women, ≤ 300 μg/L for men;
§
P-value for the study group effect. Nominal P-values are compared with 0.0083 (0.05/6) to assess significance with a 5% type 1 error rate