Skip to main content
. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Neuropharmacology. 2008 Aug 19;56(1):161–173. doi: 10.1016/j.neuropharm.2008.08.010

Table 1.

Summary of the changes in macroscopic current properties for synaptic and extrasynaptic GABAA receptor isoforms (4 sec application of 1 mM GABA vs co-application of 1 mM GABA and 1 mM penicillin)

Ipeak amplitude Desensitization Deactivation
α1β3γ2L ↓ ↑ ↑
α1β3δ ↓ ↓ ↑
α4β3γ2L ↓ ↓ ↑
α4β3δ ↓ ↓ ↑
α5β3γ2L ↓ ↓ ↑
α5β3δ NS ↓ NS
α6β3γ2L ↓ NS ↑
α6β3δ ↓ ↑ ↑

↑/↓, denotes increased or decreased peak current amplitude, extent of desensitization, or weighted deactivation time constant; NS, not significantly different from the GABA control current.