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. Author manuscript; available in PMC: 2009 May 15.

Published in final edited form as: Bioorg Med Chem Lett. 2008 Jan 8;18(10):3047–3051. doi: 10.1016/j.bmcl.2008.01.003

Table 3.

Kinetic parameters for inactivation of LSD1, MAO B, and MAO A by trans-2-phenylcyclopropylamine derivatives.

	LSD1			MAO B			MAO A
Inhibitor	k_inact (s⁻¹)	K_I (µM)	k_inact/K_I (M ⁻¹s⁻¹)	k_inact (s⁻¹)	K_I(µM)	k_inact/K_I (M⁻¹s ⁻¹)	k_inact (s⁻¹)	K_I (µM)	k_inact/K_I (M⁻¹s⁻¹)
2-PCPA	0.026 ± 0.001	477 ± 79	55	0.024 ± 0.002	13.6 ± 3.0	1779	0.018 ± 0.001	37.3 ± 8.4	469
7	N.D.^a	N.D.	< 1	N.D.	N.D.	< 1.5	N.D.	N.D.	< 14
8	N.D.	N.D.	< 28	0.047 ± 0.001	9.8 ± 0.6	4837	0.014 ± 0.001	38.7 ± 8.3	362
9	0.067 ± 0.008	352 ± 95	190	0.058 ± 0.002	7.7 ± 1.4	7507	0.085 ± 0.004	29.8 ± 3.3	2859
10	0.104 ± 0.007	566 ± 73	184	0.078 ± 0.005	32.9 ± 9.1	2356	0.070 ± 0.005	36.5 ± 6.2	1918
11	0.049 ± 0.004	188 ± 52	262	0.070 ± 0.002	86.6 ± 7.8	802	0.023 ± 0.001	20.5 ± 3.0	1112
12	N.D.	N.D.	< 10	0.035 ± 0.005	1548 ± 312	22.3	N.D.	N.D.	< 18

^a

N.D., not determined.