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A CK1 inhibitor attenuates Ser20 site phosphorylation of p53 and p53 induction mediated by HHV-6B infection. A-C, MOLT-3 cells were infected with (even-numbered lanes) or without (odd-numbered lanes) HHV-6B for 48 h in the presence of increasing concentrations (10-100 μm) of the CK1 inhibitor D4476 (lanes 3-14) or a DMSO solvent control (lanes 1 and 2). Cell lysates were examined by Western blotting with antibodies against the indicated proteins.
