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. 2008 Oct 17;283(42):28595–28606. doi: 10.1074/jbc.M805766200

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Copyright © 2008, The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 3. — Effects of protease inhibitors on rhinovirus-induced cytosolic superoxide anion () production. A, effects of serine protease inhibitors PMSF, leupeptin (Leu), pepstatin (Pep), aprotinin (Apr) on RV16-induced cytosolic production in A549 cells (n = 5). B (n = 7) and C (n = 6), effects of metalloprotease inhibitor phenanthroline (Phe)(B) or cysteine protease inhibitor E-64 (C) on RV16-induced cytosolic production in A549 cells. In A-C, where indicated (+) cells were pretreated for 4 h with protease inhibitors, then exposed, for 20 min (empty bars) or 1 h (filled bars) to RV16 or medium alone (in A, ^*** p < 0.001 versus all other conditions; B and C, ^*** p < 0.001 versus medium alone treated cells with or without inhibitor pre-treatment).

Inline graphic — Effects of protease inhibitors on rhinovirus-induced cytosolic superoxide anion () production. A, effects of serine protease inhibitors PMSF, leupeptin (Leu), pepstatin (Pep), aprotinin (Apr) on RV16-induced cytosolic production in A549 cells (n = 5). B (n = 7) and C (n = 6), effects of metalloprotease inhibitor phenanthroline (Phe)(B) or cysteine protease inhibitor E-64 (C) on RV16-induced cytosolic production in A549 cells. In A-C, where indicated (+) cells were pretreated for 4 h with protease inhibitors, then exposed, for 20 min (empty bars) or 1 h (filled bars) to RV16 or medium alone (in A, ^*** p < 0.001 versus all other conditions; B and C, ^*** p < 0.001 versus medium alone treated cells with or without inhibitor pre-treatment).