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Tyrosine nitration of eosinophil granule toxins is mediated by EPO in the presence of H2O2 and a nitrite source. Fluorescence micrographs of eosinophils from a wild type mouse (A) and an interleukin 5-transgenic, homozygous null EPO (EPO-/-) mouse (B), from an otherwise healthy human individual (C) and a CGD patient stained for 3NT, green; MBP, red; and DAPI, blue (D) Original magnification: ×1000.
