Figure 3.

Apoe mRNA expression positively correlated with MWM impairment. Individual microarray-derived Apoe gene expression measures (y-axis) are plotted as a function of retention latency during water maze performance (x-axis) for 12- and 23-month-old animals. There was a significant (p = 0.003; Pearson's test) correlation across 12 plus 23 month subjects (solid line indicates regression, with dashed lines representing 95% confidence intervals). Correlations within the 12- and 23-month-old groups separately were also significant (12 months, p = 0.04; 23 months, p = 0.05). r values for correlations within 12 months, 23 months, and 12 plus 23 months combined data are shown in the graph.