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. Author manuscript; available in PMC: 2010 Mar 1.

Published in final edited form as: Biol Blood Marrow Transplant. 2009 Mar;15(3):370–376. doi: 10.1016/j.bbmt.2008.12.491

A) Patient 5 following four months treatment with voriconazole 200mg BID. Marked hyperpigmentation on the photoexposed surfaces of the face; B) pigmentation is significantly improved one year later; C) pathology demonstrated hyperkeratosis, acanthosis, destruction of the basal epidermal layer with necrotic keratinocytes, and a sparse lymphocytic infiltrate with frequent pigmented macrophages (hematoxylin and eosin, magnification 10x).

A) Patient 5 following four months treatment with voriconazole 200mg BID. Marked hyperpigmentation on the photoexposed surfaces of the face; B) pigmentation is significantly improved one year later; C) pathology demonstrated hyperkeratosis, acanthosis, destruction of the basal epidermal layer with necrotic keratinocytes, and a sparse lymphocytic infiltrate with frequent pigmented macrophages (hematoxylin and eosin, magnification 10x).